MedicalPoint International Hospital Prof. Metin Ozgen Rheumatology

Prof. Metin Özgen, M.D.

MedicalPoint Izmir Hospital
Rheumatology

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Name

Education and Expertise

  • 1991 – 1994: İzmir Atatürk High School
  • 1994 – 2000: Ondokuz Mayıs University Faculty of Medicine
  • 2001 – 2006: Fırat University Internal Medicine Specialty Training
  • 2008 – 2011: Fırat University Rheumatology Subspecialty Training
  • 2012: Associate Professor – Malatya İnönü University
  • 2020: Professor – Ondokuz Mayıs University

Diseases

  • Familial Mediterranean Fever (FMF)

  • Ankylosing Spondylitis

  • Behçet’s Disease

  • Granulomatous Mastitis

  • Gout

  • Psoriatic Arthritis

  • Rheumatoid Arthritis

  • Sarcoidosis

  • Systemic Lupus Erythematosus

  • Sjögren’s Syndrome

  • Vasculitis

Treatment Methods

  • Infusion Therapies

  • Diagnostic Musculoskeletal Ultrasonography

  • Salivary Gland Biopsy

  • Ultrasound-Guided Injection to Important Joint Areas

Experience

  • 2000 – 2001: Social Security Dispensary, Sungurlu, Çorum
  • 2001 – 2006: Research Assistant, Department of Internal Medicine, Fırat University
  • 2008 – 2011: Research Assistant, Department of Rheumatology, Fırat University
  • 2012 – 2014: Associate Professor, İnönü University, Malatya
  • 2014 – 2019: Associate Professor, Ondokuz Mayıs University
  • 2020 – 2024: Professor, Ondokuz Mayıs University

Professional Memberships

  • Turkish Society of Rheumatology

  • İzmir Medical Chamber

Research Publications

2024

  • Guluzade E, Güzel B, Yalcin Kehribar D, Okuyucu M, Özgen M, Avcı B. The Role of Tenascin-C in the Physiopathology of Familial Mediterranean Fever. Cureus. 2024 Jul 8;16(7):e64067. doi: 10.7759/cureus.64067.

  • Kaplan H, Yalcin Kehribar D, Okuyucu M, Ozgen M. An investigation of the relationship between Behçet’s disease and tenascin-C. Arch Rheumatol. 2024 Jan 15;39(1):107-114. doi: 10.46497/ArchRheumatol.2024.10163.

2023

  • İnanç GN, Terzioğlu ME, Karabulut Y, Yılmaz Z, Tarhan EF, Enecik ME, Şahin A, Küçük A, Ayan A, Özgen M, Karasu U, Yolbaş S. A national, multicenter, retrospective study evaluating retention rate and efficacy of tocilizumab treatment in patients with active rheumatoid arthritis who had an inadequate response to csDMARDs and/or TNF inhibitors. Turk J Med Sci. 2023 Jun;53(3):731-743. doi: 10.55730/1300-0144.5636

  • Temiz Karadag D, Yalcinkaya Y, Akdogan A, Avanoglu A, Bes C, Birlik AM, Cefle A, Erdogan M, Hatemi G, Icacan OC, Inanc M, Inanc N, Koca SS, Kucuksahin O, Ozgen M, Sari A, Sahin A, Senel S, Tufan A, Ugurlu S, Yargucu Zihni F, Yolbas S, Hamuryudan V. Treatment of systemic sclerosis-associated digital ulcers: recommendations of the Turkish Society for Rheumatology. Clin Exp Rheumatol. 2023 Aug;41(8):1679-1687. doi: 10.55563/clinexprheumatol/ce13vk (Q2)

2022

  • Çoksevim M, Çerik İB, Yenerçağ M, Kocasarı AO, Yavuzbilge G, Polat M, Meriç M, Özgen M. Assessment of pulmonary arterial stiffness in patients with systemic sclerosis without overt pulmonary hypertension. Int J Cardiovasc Imaging. 2022 Oct;38(10):2191-2197. doi: 10.1007/s10554-022-02625-9

  • Kehribar DY, Emmungil H, Türkmen NB, Çiftçi O, Salva E, Özgen M. EGFR blocker lapatinib inhibits the synthesis of matrix metalloproteinases from synovial fibroblasts. Turk J Med Sci. 2022 Aug;52(4):1355-1361. doi: 10.55730/1300-0144.5442

  • Okuyucu M, Yalcin Kehribar D, Çapraz M, Çapraz A, Arslan M, Çelik ZB, Usta B, Birinci A, Ozgen M. The Relationship Between COVID-19 Disease Severity and Zonulin Levels. Cureus. 2022 Aug 22;14(8):e28255. doi: 10.7759/cureus.28255.

  • Okuyucu M, Ozdemir AZ, Yalcin Kehribar D, Ozgen M. Ovarian Reserve and Pelvic Ultrasound Assessment in Familial Mediterranean Fever. Cureus. 2022 Aug 15;14(8):e28027. doi: 10.7759/cureus.28027

  • Akyol L, Toz B, Bayındır Ö, Zengin O, Cansu D, Yiğit M, Çetin GY, Omma A, Erden A, Küçükşahin O, Altuner MŞ, Çorba B, Ünal AU, Küçük H, Küçük A, Balkarli A, Gönüllü E, Tufan AN, Bakırcı S, Öner SY, Balcı MA, Kobak Ş, Yazıcı A, Özgen M, Şahin A, Koca SS, Erer B, Gül A, Aksu K, Keser G, Onat AM, Kısacık B, Kaşifoğlu T, Çefle A, Kalyoncu U, Sayarlıoğlu M. Budd-Chiari syndrome in Behçet’s disease: a retrospective multicenter study. Clin Rheumatol. 2022 Jan;41(1):177-186. doi: 10.1007/s10067-021-05878-2. (Q2)

2021

  • Yalcin Kehribar D, Gunaydin S, Ozgen M. Infliximab therapy in parenchymal neuro-Behçet’s disease: A single-center experience. Int J Rheum Dis. 2021 Oct;24(10):1302-1307. doi: 10.1111/1756-185X.14209.

  • Yalçın Kehribar D, Özgen M, Yolbaş S, Yıldırım A, Önalan Etem E, Çiftçi O, Özercan İH, Koca SS. The inhibition of Src kinase suppresses the production of matrix metalloproteinases in synovial fibroblasts and inhibits MAPK and STATs pathways. Turk J Med Sci. 2021 Aug 30;51(4):2142-2149. doi: 10.3906/sag-2008-274.

  • The receptor for advanced glycation end product (RAGE) pathway in COVID-19. Yalcin Kehribar D, Cihangiroglu M, Sehmen E, Avci B, Capraz A, Yildirim Bilgin A, Gunaydin C, Ozgen M. Biomarkers. 2021 Mar;26(2):114-118. doi: 10.1080/1354750X.2020.1861099. (Q2)

  • Kır S, Özgen M, Zontul S. Adult-onset Still’s disease and treatment results with tocilizumab. Int J Clin Pract. 2021 Mar;75(3):e13936. doi: 10.1111/ijcp.13936. (Q2)

2020

  • Duran TI, Kehribar DY, Ozgen M. Adult-onset Still’s Disease Detected in Ankylosing Spondylitis Patient using Adalimumab. J Coll Physicians Surg Pak. 2020 Dec;30(12):1364. doi: 10.29271/jcpsp.2020.12.1364.

  • Yalçın Kehribar D, Cihangiroğlu M, Sehmen E, Avcı B, Çapraz M, Boran M, Günaydin C, Özgen M. The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID–19. Turk J Med Sci. 2020 Dec 17;50(8):1786-1791. doi: 10.3906/sag-2006-96.

  • Kehribar DY, Duran TI, Polat AK, Ozgen M. Effectiveness of Methotrexate in Idiopathic Granulomatous Mastitis Treatment. Am J Med Sci. 2020 Nov;360(5):560-565. doi: 10.1016/j.amjms.2020.05.029. (Q2)

  • Kehribar DY, Ozgen M. Infliximab treatment in refractory vascular Behcet’s disease: A single-center experience. Vascular. 2020 Dec;28(6):829-833. doi: 10.1177/1708538120927701.

  • Karatas A, Dagli AF, Orhan C, Gencoglu H, Ozgen M, Sahin N, Sahin K, Koca SS. Epigallocatechin 3-gallate attenuates arthritis by regulating Nrf2, HO-1, and cytokine levels in an experimental arthritis model. Biotechnol Appl Biochem. 2020 May;67(3):317-322. doi: 10.1002/bab.1860. (Q2)

  • Kehribar DY, Özgen M. The importance of Mediterranean fever gene in familial Mediterranean fever. Eur J Rheumatol. 2020 Jul 21;7(4):173-6. doi: 10.5152/eurjrheum.2020.20107. (Q2)

  • Kehribar DY, Özgen M. Efficacy of anti-interleukin-1 treatment in colchicine-resistant arthritis in patients with familial Mediterranean fever. Eur J Rheumatol. 2021 Jan;8(1):16-19. doi: 10.5152/eurjrheum.2020.20126 (Q2)

  • Gürbüz C, Yalçın Kehribar D, Özgen M. Clinical manifestations of Behçet’s syndrome: A single-center cohort of 777 patients. Eur J Rheumatol. 2021 Oct;8(4):211-216. doi: 10.5152/eurjrheum.2020.21199. (Q2)

  • Duran Tİ, Özgen M. Two cases of calcium pyrophosphate deposition disease (CPPD) presented with spondylodiscitis. Eur J Rheumatol. 2020 Apr;7(2):84-87. doi: 10.5152/eurjrheum.2020.19180. (Q2)

During Associate Professorship Process

  • Gül FC, Turgut B, Dağlı F, Ilhan N, Özgen M. The comparison of the impact of ghrelin and tacrolimus on vitreous cytokine levels in an experimental uveitis model. Graefes Arch Clin Exp Ophthalmol. 2013 Apr;251(4):1235-41. doi: 10.1007/s00417-013-2259-x

  • Turgut B, Gül FC, Dağli F, Ilhan N, Özgen M. Impact of ghrelin on vitreous cytokine levels in an experimental uveitis model. Drug Des Devel Ther. 2013;7:19-24. doi: 10.2147/DDDT.S39453

  • Koca SS, Akbas F, Ozgen M, Yolbas S, Ilhan N, Gundogdu B, Isik A. Serum galectin-3 level in systemic sclerosis. Clin Rheumatol. 2014 Feb;33(2):215-20. doi: 100.1007/s10067-013-2346-8 (Q2)

  • Koca SS, Kara M, Ozgen M, Dagli MN, Gozel N, Yolbas S, Gundogdu B, Kargun K, Isik A. The rs3768777-G allele of ITGAV gene is associated with rheumatoid arthritis. Rheumatol Int. 2014 May;34(5):693-8. doi: 10.1007/s00296-013-2925-7 (Q2)

  • Koca SS, Kara M, Deniz F, Ozgen M, Demir CF, Ilhan N, Isik A. Serum IL-33 level and IL-33 gene polymorphisms in Behçet’s disease. Rheumatol Int. 2015 Mar;35(3):471-7. doi: 10.1007/s00296-014-3111-2.

  • Karatas A, Koca SS, Ozgen M, Dagli AF, Erman F, Sahin N, Sahin K, Isik A. Pemetrexed ameliorates experimental arthritis in rats. Inflammation. 2015 Feb;38(1):9-15. doi: 10.1007/s10753-014-0002-3. (Q2)

  • Ozgen M, Koca SS, Karatas A, Dagli AF, Erman F, Gundogdu B, Sahin K, Isik A. Lapatinib ameliorates experimental arthritis in rats. Inflammation. 2015 Feb;38(1):252-9. doi: 10.1007/s10753-014-0028-6. (Q2)

  • Akyol L, Aslan K, Özgen M, Sayarlioglu M. Bilateral sacroiliitis and uveitis comorbidity: brucellosis? Ankylosing spondylitis? BMJ Case Rep. 2015 Sep 22;2015. pii: bcr2015211461. doi: 10.1136/bcr-2015-211461

  • Oztuzcu S, Onat AM, Pehlivan Y, Alibaz-Oner F, Donmez S, Cetin GY, Yolbas S, Bozgeyik I, Yilmaz N, Ozgen M, Cagatay Y, Kisacik B, Koca SS, Pamuk ON, Sayarlioglu M, Direskeneli H, Demiryurek AT. Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis. In Vivo. 2015 Nov-Dec;29(6):763-70. (Q2)

  • Akyol L, Aslan K, Özgen M, Sayarlıoğlu M. A rare comorbidity: neurosarcoidosis and cutaneous sarcoidosis. BMJ Case Rep. 2015 Nov 17;2015. pii: bcr2015211439. doi: 10.1136/bcr-2015-211439.

  • Pehlivan Y, Yolbas S, Cetin GY, Alibaz-Oner F, Cagatay Y, Yilmaz N, Oztuzcu S, Donmez S, Ozgen M, Koca SS, Pamuk ON, Sayarlıoğlu M, Kisacik B, Direskeneli H, Demiryurek AT, Onat AM. Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis. Rheumatol Int. 2016 Mar;36(3):421-7. doi: 10.1007/s00296-015-3400-4. (Q1)

  • Koca SS, Pehlivan Y, Kara M, Alibaz-Oner F, Oztuzcu S, Yilmaz N, Cetin GY, Kisacik B, Ozgen M, Pamuk ON, Direskeneli H, Sayarlioglu M, Onat AM. The IL-33 gene is related to increased susceptibility to systemic sclerosis. Rheumatol Int. 2016 Apr;36(4):579-84. doi: 10.1007/s00296-015-3417-8.

  • Koca SS, Ozgen M, Dagli AF, Gozel N, Ozercan IH, Isik A. The Protective Effects of Bevacizumab in Bleomycin-Induced Experimental Scleroderma. Adv Clin Exp Med. 2016 Mar-Apr;25(2):249-53. doi: 10.17219/acem/32484. (Q1)

  • Dağli AF, Karataş A, Orhan C, Tuzcu M, Özgen M, Şahin K, Koca SS. Antiinflammatory and antioxidant effects of gemcitabine in collagen-induced arthritis model. Turk J Med Sci. 2017 Jun 12;47(3):1037-1044. doi: 10.3906/sag-1606-80.

  • Koca SS, Kara M, Özgen M, Dayanan R, Demir CF, Aksoy K, İlhan N, Dönder E, Işık A. Low prevalence of obesity in Behçet’s disease is associated with high obestatin level. Eur J Rheumatol. 2017 Jun;4(2):113-117. doi: 10.5152/eurjrheum.2017.160095.

International Peer-Reviewed Articles

  • Koca SS, Kara M, Özgen M, Dayanan R, Demir CF, Aksoy K, İlhan N, Dönder E, Işık A. Low prevalence of obesity in Behçet’s disease is associated with high obestatin level. Eur J Rheumatol. 2017 Jun;4(2):113-117. doi: 10.5152/eurjrheum.2017.160095.

  • Akar S, Cetin P, Kalyoncu U, Karadag O, Sari I, Cınar M, Yilmaz S, Onat AM, Kisacik B, Erden A, Balkarli A, Kucuksahin O, Oner SY, Senel S, Tufan A, Direskeneli H, Oksuz F, Pehlivan Y, Bayindir O, Keser G, Aksu K, Omma A, Kasifoglu T, Unal AU, Yildiz F, Balci MA, Yavuz S, Erten S, Ozgen M, Sayarlıoglu M, Dogru A, Yildirim G, Oner FA, Tezcan ME, Pamuk ON, Onen F. Nationwide Experience With Off-Label Use of Interleukin-1 Targeting Treatment in Familial Mediterranean Fever Patients. Arthritis Care Res (Hoboken). 2018 Jul;70(7):1090-1094. doi: 10.1002/acr.23446. (Q1)

  • Yolbaş S, Yıldırım A, Düzenci D, Gündoğdu B, Özgen M, Koca SS. Sleep quality, sleeping postures, and sleeping equipment in patients with ankylosing spondylitis. Turk J Med Sci. 2017 Aug 23;47(4):1198-1205. doi: 10.3906/sag-1605-62.

  • Kir S, Akyol L, Özgen M, Pinar Günbey H, Sayarlioğlu M. Ptosis and Mass Like Lesions in Behçet’s Disease: A Rare Presentation. Arch Rheumatol. 2017 Oct 16;33(2):221-224. doi: 10.5606/ArchRheumatol.2018.6515.

  • Koca SS, Özgen M, Işık B, Dağlı MN, Üstündağ B, Işık A. Serum salusin-α levels in systemic lupus erythematosus and systemic sclerosis. Eur J Rheumatol. 2014 Mar;1(1):14-17. (Q2)

  • Akyol L, Önem S, Özgen M, Sayarlıoğlu M. Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia in a patient with systemic lupus erythematosus and lupus nephritis. Eur J Rheumatol. 2016 Mar;3(1):36-37. (Q2)

  • Akyol L, Önem S, Özgen M, Sayarlıoğlu M. Sjögren’s syndrome after silicone breast implantation. Eur J Rheumatol. 2015 Dec;2(4):165-166. (Q2)

  • Akyol L, Günbey E, Karlı R, Önem S, Özgen M, Sayarlıoğlu M. Evaluation of olfactory function in Behçet’s disease. Eur J Rheumatol. 2016 Dec;3(4):153-156. doi: 10.5152/eurjrheum.2016.017 (Q2)

  • Işıklı G, Akyol L, Uçak SS, Aslan K, Özgen M, Sayarlıoğlu M. Heterotopic ossification (myositis ossificans progressiva): A condition interfering with rheumatic disease. Eur J Rheumatol. 2017 Mar;4(1):79-80. doi: 10.5152/eurjrheum.2016.15061 (Q2)

    Pre-Associate Professorship

  • S.Koca, M.Ozgen, S.Aydin, S.Dag, B.Evren, A.Isik. Ghrelin and obestatin levels in rheumatoid arthritis. Inflammation. 2008;31(5):329-35. (Q2)

  • Dogukan, E.Ilkay, O.K.Poyrazoglu, A.I.Gunal, M.Ozgen, M.Pekdemir. Atrial fibrillation due to oral methylprednisolone in a patient with membranoproliferative glomerulonephritis. Acta Medica (Hradec Kralove). 2008;51(1):63-4.

  • S.Koca, O.Ateş, B.Üstündağ, U.Çeliker, M.Ozgen, A.Isik. Serum prohepcidin level in Behçet’s disease. Turkiye Klinikleri J Med Sci. 2008;28:601-605.

  • S.Koca, I.Karaca, M.F.Yavuzkir, N.Dagli, M.Ozgen, B.Ustündağ, A.Işik. Insulin resistance is related with oxidative stress in systemic lupus erythematosus. Anadolu Kardiyol Derg. 2009;9(1):23-8.

  • S.Koca, E.O.Etem, B.Isik, H.Yuce, M.Ozgen, M.S.Dag, A.Isik. Prevalence and significance of MEFV gene mutations in a cohort of patients with rheumatoid arthritis. Joint Bone Spine. 2010;77(1):32-5. (Q2)

  • Ozgen, S.S.Koca, A.Isik, I.H.Ozercan. Methotrexate has no antifibrotic effect in bleomycin-induced experimental scleroderma. J Rheumatol. 2010;37(3):678-9. (Q1)

  • Akbulut, S.S.Koca, M.Ozgen, A.Isik. Anti-tumor necrosis factor therapies reduce serum macrophage inflammatory protein-1alpha in ankylosing spondylitis. J Rheumatol. 2010;37(5):1073-4. (Q1)

  • Ozgen, S.S.Koca, N.Dagli, M.Balin, B.Ustundag, A.Isik. Serum adiponectin and vaspin levels in rheumatoid arthritis. Arch Med Res. 2010;41(6):457-63. (Q1)

  • Ozgen, S.S.Koca, E.O.Etem, H.Yuce, S.Aydin, A.Isik. Ghrelin gene polymorphisms in rheumatoid arthritis. Joint Bone Spine. 2011;78(4):368-73. (Q2)

  • Ozgen, S.S.Koca, K.Aksoy, N.Dagli, B.Ustundag, A.Isik. Visfatin levels and intima-media thicknesses in rheumatic diseases. Clinical Rheumatology 2011;30(6):757-63. (Q2)

  • Ozgen, S.S.Koca, N.Dagli, M.Balin, B.Ustundag, A.Isik. Serum salusin-alpha level in rheumatoid arthritis. Regulatory Peptides. 2011;167(1):125-8. (Q2)

  • Ozgen, S.S.Koca, B.Isik, N.Dagli, B.Ustundag, A.Isik. Serum adiponectin and vaspin levels in systemic sclerosis. Turkish Journal of Biochemistry. 2011;36(1);35–42.

  • S.Koca, M.Ozgen, F.Dagli, M.Tuzcu, I.H.Ozercan, K.Sahin, A.Isik. Anti-fibrotic effects of proteasome inhibition in bleomycin-induced experimental scleroderma. Inflammation. (2011) DOI: 10.1007/s10753-011-9380-y (Q2)

  • Pehlivan, B.Gogebakan, S.Oztuzcu, M.Ozgen, G.Y.Cetin, R.Bayraktar, B.Kisacik, S.S.Koca, S.Donmez, M.Sayarlioglu, A.T.Demiryurek, A.M.Onat. Association between Thr21Met and Ser89Asn polymorphisms of the urotensin II gene and systemic sclerosis. J Rheumatol. (2011) DOI:10.3899/jrheum.110509 (Q1)

  • Ozgen M, Koca SS, Dagli AF, Gundogdu B, Ustundag B, Isik A. Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-induced experimental scleroderma. Clin Exp Dermatol. 2012 Jan;37(1):48-54. doi: 10.1111/j.1365-2230.2011.04201.x. (Q2)

    Other International Journal Articles

  • Yalcin Kehribar Demet, Ozgen M. The Experience of Interleukin-1 Inhibition in Patients with Familial Mediterranean Fever. Journal of Experimental and Clinical Medicine, 38(1), 27-31. doi: 10.5835/jecm.omu.38.01.006.

  • Yalcin Kehribar Demet, Okuyucu Muhammed, Ozgen Metin, Ketenci Yusuf Bunyamın, Ayyıldız Talat, Yıldırım Beytullah. Impact of Tumor Necrosis Factor Alpha Antagonist Treatment on Antibody Titer of Hepatitis B Surface Antigen. Journal of Surgery and Medicine, 4(8), 678-681. doi: 10.28982/josam.777871.

  • Yalcin Kehribar Demet, Izci Duran Tugba, Karakurt Cetinkaya Gamze, Kamalı Polat Ayfer, Ozgen M. Evaluation of Symptoms, Depression and Anxiety Levels in Young Women with Idiopathic Granulomatous Mastitis. International Journal of Academic Medicine and Pharmacy, 2(2), 57-61. doi: 0000-0002-1852-7981.

    National Peer-Reviewed (TÜBİTAK-Ulakbim) Journal Articles

  • Demet Yalçın Kehribar, Metin Özgen. Clinical Characteristics of Patients with Vascular Involvement in Behçet’s Disease. Tepecik Training and Research Hospital Journal, 2020;30(2):122-6. doi:10.5222/terh.2020.86094

  • Özlem Evecen Erişmiş, Demet Yalçın Kehribar, Metin Özgen. Comparison of Early-Onset and Late-Onset Rheumatoid Arthritis Patients. Firat Medical Journal, 2020;25(4):179-183.

  • K.Poyrazoğlu, A.Doğukan, S.S.Koca, M.Özgen, A.İ.Günal, H.G. Poyrazoğlu. Two Siblings with Familial Juvenile Hyperuricemic Nephropathy: A Case Report. Turkish Nephrology Dialysis and Transplantation Journal 2003:12;233-5.

  • Çelebi, A.Karaoğlu, H.Çelik, E.T. Elkıran, S.Yazıcı, M.Özgen, İ.H. Özercan. Early Intramucosal Gastric Cancer with Krukenberg Tumor: A Case Report. Firat University Medical Journal, 2005:10;182-4.

  • S.Koca, A.Işık, H.Çeliker, M.Özgen. Ulcerative Pyoderma Gangrenosum and CIDP Associated with Chronic Renal Failure: A Case Report and Literature Review. Firat University Medical Journal, 2008;8(6):363-368.

  • S.Koca, M.Özgen, A.Işık. Experimental Animal Models in Scleroderma. Turkiye Klinikleri Journal of Immunology and Rheumatology – Special Topics, 2009;2(3):50-7.

  • Özgen, Y.Özkan, S.S.Koca, A.Işık. The effects of lifestyle changes, sibutramine and orlistat in obese adults. Turkiye Klinikleri Journal of Cardiovascular Science, 2010;22(1):12-8.

  • Özgen, S.S.Koca. Etiopathogenesis and Current Treatment of Scleroderma. Firat University Medical Journal, 2010;24(1):69-76.

    S.Koca, M.Özgen, A.Işık. Treatment in Autoimmune Diseases. Turkiye Klinikleri Journal of Immunology and Rheumatology – Special Topics, 2011;4(2):92-8.

    Abstracts Presented and Published in International Scientific Meetings

  • S.Koca, E.O.Etem, B.Isik, H.Yuce, S.Dag, M.Ozgen, A.Isik. Prevalence and significance of MEFV gene mutations in a cohort of patients with rheumatoid arthritis. Annual European Congress of Rheumatology, EULAR 2008, Paris, 11-14 June 2008. Annals of Rheumatic Diseases EULAR 2008 (145 pp.)

  • S.Koca, M.Ozgen, S.Aydin, S.Dag, A.Isik. Decreased ghrelin and increased obestatin in rheumatoid arthritis. Annual European Congress of Rheumatology, EULAR 2008, Paris, 11-14 June 2008. Annals of Rheumatic Diseases EULAR 2008 (289 pp.)

  • Ozgen, S.Koca, F.Dagli, K.Metin, B.Evren, A.Isik. Protective effects of mycophenolate mofetil and daclizumab in bleomycin-induced experimental scleroderma. Annual European Congress of Rheumatology, EULAR 2009, Copenhagen, Denmark, 10-13 June 2009. Annals of Rheumatic Diseases EULAR 2009 (212-213 pp.)

  • Ozgen, S.Koca, F.Dagli, H.Akbulut, S.Dag, A.Isik. Methotrexate has no anti-fibrotic effect in bleomycin-induced experimental scleroderma. Annual European Congress of Rheumatology, EULAR 2009, Copenhagen, Denmark, 10-13 June 2009. Annals of Rheumatic Diseases EULAR 2009 (213 pp.)

  • Ozgen, S.Koca, F.Dagli, B. Isik, I.Ozercan, A.Isik. Protective effects of bevacizumab and genistein in bleomycin-induced experimental scleroderma. Annual European Congress of Rheumatology, EULAR 2009, Copenhagen, Denmark, 10-13 June 2009. Annals of Rheumatic Diseases EULAR 2009 (213 pp.)

  • Aksoy, M.Ozgen, S.Koca, N.Dagli, B.Ustundag, A.Isik. Visfatin levels and intima-media thicknesses in rheumatoid arthritis and systemic lupus erythematosus. Annual European Congress of Rheumatology, EULAR 2009, Copenhagen, Denmark, 10-13 June 2009. Annals of Rheumatic Diseases EULAR 2009 (570 pp.)

  • Ozgen, S.Koca, E.O.Etem, H.Yuce, S.Aydin, A.Isik. The role of ghrelin gene polymorphisms in patients with rheumatoid arthritis. Annual European Congress of Rheumatology, EULAR 2009, Copenhagen, Denmark, 10-13 June 2009. Annals of Rheumatic Diseases EULAR 2009 (727 pp.)

  • S.Koca, M.Ozgen, I.Ozercan, F.Dagli, B.Ustundag, A.Isik. Anti-fibrotic effects of proteasome inhibition on bleomycin-induced experimental scleroderma. 1st Systemic Sclerosis World Congress, Florence Italy, 11-13 February 2010. Clinical and Experimental Rheumatology (32 pp.)

  • Ozgen, S.S.Koca, B.Ustundag, I.Ozercan, F.Dagli, A.Isik. Anti-fibrotic effects of cyclophosphamide on bleomycin-induced experimental scleroderma. 1st Systemic Sclerosis World Congress, Florence Italy, 11-13 February 2010. Clinical and Experimental Rheumatology (89 pp.)

  • Ozgen, S.S.Koca, B.Isik, N.Dagli, B.Ustundag, A.Isik. Adiponectin and vaspin levels in systemic sclerosis. 1st Systemic Sclerosis World Congress, Florence, Italy, 11-13 February 2010. Clinical and Experimental Rheumatology (103 pp.)

  • Ozgen, S.S.Koca, B.Isik, N.Dagli, B.Ustundag, A.Isik. Serum salusin-alpha level in systemic sclerosis. 1st Systemic Sclerosis World Congress. Florence Italy, 11-13 February 2010. Clinical and Experimental Rheumatology (p103 pp.)

  • Ozgen, S.S.Koca, N.Dagli, M.Balin, B.Ustundag, A.Isik. Serum salusin-α levels in patients with rheumatoid arthritis. Annual European Congress of Rheumatology, EULAR 2010, Rome, Italy, 16-19 June 2010. Annals of Rheumatic Diseases EULAR 2010 (516 pp.)

  • Ozgen, S.S.Koca, B.Isik, B.Ustundag, A.F.Dagli, A.Isik. Effectiveness of gemcitabine treatment in bleomycin-induced experimental scleroderma. Annual European Congress of Rheumatology, EULAR 2010, Rome, Italy, 16-19 June 2010. Annals of Rheumatic Diseases EULAR 2010 (419 pp.)

  • Ozgen, S.S.Koca, M.Sarikaya, I.H. Ozercan, B.Ustundag, A.Isik. Effectiveness of ghrelin treatment in bleomycin-induced experimental scleroderma. Annual European Congress of Rheumatology, EULAR 2010, Rome, Italy, 16-19 June 2010. Annals of Rheumatic Diseases EULAR 2010 (419 pp.)

  • Ozgen, S., S.S. Koca, Y. Dik, B. Ustundag, I.H. Ozercan, A. Isik. Effectiveness of rituximab treatment in bleomycin-induced experimental scleroderma. Annual European Congress of Rheumatology, EULAR 2010, Rome, Italy, 16-19 June 2010. Annals of Rheumatic Diseases EULAR 2010 (pp. 419).

  • Ozgen, S., S.S. Koca, M. Balin, M.N. Dagli, B. Ustundag, A. Isik. Serum adiponectin and vaspin levels in rheumatoid arthritis. Annual European Congress of Rheumatology, EULAR 2010, Rome, Italy, 16-19 June 2010. Annals of Rheumatic Diseases EULAR 2010 (pp. 677).

  • Ozgen, S., S.S. Koca, N. Dagli, M. Balin, B. Ustundag, A. Isik. Serum adiponectin and vaspin levels in Behcet’s disease. The 14th International Conference on Behcet’s Disease, Queen Mary College, University of London, 8-10 July 2010. Abstract Book (pp. 62-63).

  • Ozgen, S., S.S. Koca, N. Dagli, M. Yavuzkir, B. Ustundag, A. Isik. Serum salusin-α level in Behcet’s disease. The 14th International Conference on Behcet’s Disease, Queen Mary College, University of London, 8-10 July 2010. Abstract Book (pp. 63-64).

National Congress and Symposium Abstracts

  • Karaoglu, S., Çelebi, H., Çelik, H., Ataseven, S., Yazici, M., Ozgen, I.H. Ozercan. Early Gastric Cancer with Krukenberg Tumor: A Case Report. 4th East-Southeast Anatolia Hepato-Gastroenterology Symposium, 3-6 June 2004, Elazig (pp. 78).

  • Karaoglu, E.T., Elkiran, E., Topkan, M., Ozgen, A., Gencaslan, B., Evren. Epidermoid Breast Cancer: A Case Report. 3rd National Medical Oncology Congress, 6-10 September 2006, Antalya (pp. 60).

  • Özkan, M., Ozgen, B., Ustündag, R., Colak. Effects of Orlistat and Sibutramine Treatment on Serum Adiponectin and Ghrelin Levels. 8th National Internal Medicine Congress, 13-17 September 2006, Antalya (pp. 204).

  • S. Koca, M. Ozgen, A.F. Dagli, I.H. Ozercan, A. Isik. Effectiveness of genistein and bevacizumab treatments in bleomycin-induced experimental scleroderma model. 9th National Rheumatology Congress, 11-15 October 2008, Antalya (pp. 117).

  • Ozgen, S., S.S. Koca, A.F. Dagli, S. Dag, A. Isik. Methotrexate does not show antifibrotic effect in bleomycin-induced experimental scleroderma model. 9th National Rheumatology Congress, 11-15 October 2008, Antalya (pp. 118).

  • Ozgen, S., S.S. Koca, A.F. Dagli, K. Metin, B. Evren, A. Isik. Effectiveness of daclizumab and mycophenolate mofetil treatments in bleomycin-induced experimental scleroderma model. 9th National Rheumatology Congress, 11-15 October 2008, Antalya (pp. 121).

  • Aksoy, S., S.S. Koca, M. Ozgen, N. Dagli, B. Ustundag, A. Isik. Visfatin levels and intima-media thickness in patients with rheumatoid arthritis and systemic lupus erythematosus. 9th National Rheumatology Congress, 11-15 October 2008, Antalya (pp. 138).

  • S. Koca, M. Ozgen, E.O. Etem, H. Yüce, S. Aydin, A. Isik. Frequency and clinical significance of ghrelin gene polymorphisms in patients with rheumatoid arthritis. 9th National Rheumatology Congress, 11-15 October 2008, Antalya (pp. 139).

  • Ozgen, S., S.S. Koca, N. Dagli, K. Metin, A. Isik. Visfatin levels and intima-media thickness in Behcet’s disease and scleroderma. 9th National Rheumatology Congress, 11-15 October 2008, Antalya (pp. 145).

  • Akbulut, M., Ozgen, S.S. Koca, B. Evren, A. Isik. Effects of anti-TNF treatment on serum chemokine levels in patients with rheumatoid arthritis and ankylosing spondylitis. 33rd Turkish Microbiology Congress, 21-25 October 2008, Izmir (pp. 174).

  • O. Karadag, S. Yilmaz, B. Kisacik, U. Kalyoncu, E. Tezcan, S. Yilmaz, M. Ozgen, D. Kaşkarı, H. Direskeneli, H. Kiraz, I. Erteneli, A. Dinç. Rates and reasons for biologic drug switching in rheumatic diseases: findings from RomaDigital. National Rheumatology Congress, 13-17 October 2010, Antalya (7 pp.).

  • Pehlivan, B., Gogebakan, S., Oztuzcu, M., Ozgen, G.Y., Cetin, B., Cengiz, B., Kisacik, S.S., Koca, Ö.N., Pamuk, M., Sayarlioglu, A.T., Demiryurek, A.M. Relationship between systemic sclerosis and urotensin-II gene T21 and S89N polymorphisms. National Rheumatology Congress, 13-17 October 2010, Antalya (27 pp.).

  • Ozgen, S., S.S. Koca, A.F. Dagli, A. Karatas, C. Orhan, H. Gencoğlu, N. Sahin, K. Sahin, A. Isik. Preventive and therapeutic effects of epigallocatechin-3-gallate (EGCG) in collagen-induced arthritis model in rats. 12th National Rheumatology Congress, 16-20 October 2011, Antalya (pp. 84).

  • Ozgen, S., S.S. Koca, A.F. Dagli, A. Karatas, C. Orhan, M. Tuzcu, N. Sahin, K. Sahin, A. Isik. Therapeutic effect of gemcitabine in collagen-induced arthritis model in rats. 12th National Rheumatology Congress, 16-20 October 2011, Antalya (pp. 84-85).

  • Ozgen, S., S.S. Koca, A. Karatas, A.F. Dagli, F. Erman, B. Gundogdu, K. Sahin, A. Isik. Effectiveness of lapatinib treatment in collagen-induced arthritis model in rats. 12th National Rheumatology Congress, 16-20 October 2011, Antalya (pp. 24).

  • Ozgen, S., S.S. Koca, A. Karatas, A.F. Dagli, F. Erman, N. Sahin, K. Sahin, A. Isik. Effectiveness of pemetrexed treatment in collagen-induced arthritis model in rats. 12th National Rheumatology Congress, 16-20 October 2011, Antalya (pp. 79).

  • Ozgen, S., S.S. Koca, F. Akbas, N. Ilhan, A. Karatas, A. Isik. Serum galectin-3 levels in scleroderma patients. 12th National Rheumatology Congress, 16-20 October 2011, Antalya (pp. 99-100).

National Abstracts Published During Associate Professorship

  • Kehribar, M., Ozgen. Late-Onset Familial Mediterranean Fever Cases. 19th National Rheumatology Congress, 26-30 September 2018, Izmir.

  • Kehribar, M.Ş. Altuner, M. Ozgen. Generalized morphea case that can be confused with eosinophilic fasciitis and systemic sclerosis diagnosis. 19th National Rheumatology Congress, 26-30 September 2018, Izmir.

  • Kehribar, M., Ozgen, M. Yilmaz. Late-Onset or Late Diagnosis? 20th National Internal Medicine Congress, 10-14 October 2018, Antalya.

National Abstracts Published During Professorship

  • Demet Yalçın Kehribar, Zontul Sezgin, Ozgen Metin (2018). Late-Onset Familial Mediterranean Fever Cases. 19th National Rheumatology Congress (Abstract/Poster).

  • Demet Yalçın Kehribar, Merve Yilmaz, Ozgen Metin (2018). Rare Systemic Mastocytosis Case. 19th National Rheumatology Congress (Abstract/Poster).

  • Demet Yalçın Kehribar, Merve Yilmaz, Ozgen Metin (2018). Rare Systemic Mastocytosis Case. 19th National Rheumatology Congress (Abstract/Poster).

  • Demet Yalçın Kehribar, Metin Ozgen, Merve Yilmaz. Late-Onset or Late Diagnosis? 20th National Internal Medicine Congress, Antalya (Abstract/Poster).

Turkish Book Chapter Authorship

  • Ozgen, D.Y. Kehribar, S. Kir. A 55-year-old male patient with migrating pain complaints. Clinical Rheumatology with Cases, 2019.

  • Kir, M., Ozgen. A 42-year-old male patient with 2 months of fever, sweating, weight loss and fatigue. Clinical Rheumatology with Cases, 2019.

  • Yalçın Kehribar D., Ozgen M. Autoinflammatory Diseases. Clinical Rheumatology, Kısacık Bünyamin, Bes Cemal, Koca Süleyman Serdar (Editors), Türkiye Klinikleri, pp. 550-555, 2021.

  • Kehribar L., Ozgen M. Acute Rheumatic Fever and Poststreptococcal Reactive Arthritis. Clinical Rheumatology, Kısacık Bünyamin, Bes Cemal, Koca Süleyman Serdar (Editors), Türkiye Klinikleri, pp. 642-649, 2021.

  • Metin Ozgen. Aneurysms in Rheumatology.

  • Metin Ozgen. Metabolic Myopathies.

Supervised Theses

  • Fatih Tay, 2016. Investigation of Possible Factors Indicating the Switch to Anti-TNF Therapy in Patients with Ankylosing Spondylitis.

  • Özlem Evecen, 2019. Evaluation of Clinical, Demographic, and Medical Treatments of Early and Late Onset Rheumatoid Arthritis Patients.

Projects and Roles in Projects

  • Effect of Orlistat and Sibutramine Treatment on Serum Adiponectin and Ghrelin Levels. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Serum Galectin-3 Level in Scleroderma. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Effects of Omentin and Apelin on Insulin Resistance in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Lapatinib Treatment in Experimental Arthritis Model. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Pemetrexed Treatment in Experimental Arthritis Model. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Gemcitabine Treatment in Experimental Arthritis Model. (FÜBAP-Firat University Scientific Research Projects: Principal Investigator)

  • Serum IL-33 Level and IL-33 Gene Polymorphisms in Behcet’s Disease. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Serum Ghrelin and Obestatin Levels, Ghrelin and Ghrelin Receptor Gene Polymorphisms in Behcet’s Disease. (FÜBAP-Firat University Scientific Research Projects: Researcher)

  • Serum IL-33 Level and IL-33 Gene Polymorphisms in Rheumatoid Arthritis. (RAED – Rheumatology Research and Education Association: Researcher)

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